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KMID : 0605620130200040166
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Journal of Korean Society of Biological Psychiatry
2013 Volume.20 No. 4 p.166 ~ p.178
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Sex-Related Differences of EEG Coherences between Patients with Schizophrenia and Healthy Controls
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Jung Hye-Min
Lee Yu-Sang
Kim Seong-su
Kim Seong-Kyun
Jeong Jae-Seung
Oh Jin-seok
Lee Seung-Yeoun
Kim Bum-Joon
Chang Jae-Seung
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Abstract
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Objectives: Alteration of epigenetic effects of testosterone during early development was suggested as an ancillary mechanism for the genesis of schizophrenia. EEG coherence was thought to be a marker for cerebral laterality of which important determinant was testosterone during early development. We studied sex-related differences of EEG coherences between patients with schizophrenia and controls to examine the sex effects in the genesis of schizophrenia.
Methods: EEG was recorded in 35 patients with schizophrenia and 46 healthy controls in the eyes closed resting state. Pair-wise EEG coherences were calculated over delta, theta, alpha, beta and gamma frequency bands. To examine the differences of EEG coherence according to sex in each group, ANCOVA was performed using Statistical Analysis system (SAS, Ver 9.3) and R (Ver 2.15.2).
Results: Healthy control males showed more increased right intrahemispheric coherences than healthy control females in delta, theta, alpha and beta frequency bands. In patients with schizophrenia, this male dominant pattern in right intrahemispheric coherences was attenuated especially in alpha and beta bands. Healthy control females showed more increased interhemispheric coherences than healthy control males in delta, theta, beta and gamma frequency bands. In patients with schizophrenia, these female dominant patterns in interhemispheric coherences were attenuated especially in delta, theta, and beta bands, which were commonly observed in frontal to central areas.
Conclusion: Sex differences in resting EEG coherences were attenuated in schizophrenia patients. These results imply that sex-related aberrant cerebral lateralization might exist in patients with schizophrenia, which are partly due to sex hormones via epigenetic mechanisms.
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KEYWORD
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Sex differences, Schizophrenia, EEG coherences
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